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Digestive health

Acid reflux: when a PPI makes sense — and when not to self-treat

Proton-pump inhibitors reduce stomach acid, but persistent heartburn, swallowing problems and unexplained weight loss need proper assessment.

By Dr Ahmed Said · (GPhC 2075007)6 min readUpdated 31 August 2026

What reflux feels like

Heartburn is a burning sensation behind the breastbone, often after eating or when lying down. Acid may rise into the throat and leave a sour taste. Large meals, alcohol, smoking, excess weight and some medicines can make symptoms worse, but triggers vary.

Occasional mild symptoms may respond to meal timing, smaller portions, avoiding a personal trigger and pharmacy advice. Repeated symptoms deserve review because indigestion, ulcers, medicine side effects and heart problems can sometimes feel similar.

How PPIs fit into treatment

Proton-pump inhibitors, including omeprazole and lansoprazole, reduce how much acid the stomach makes. NHS guidance notes that a clinician may use a four- or eight-week course depending on symptom severity. The medicine must be taken as directed; it is not an instant antacid.

If symptoms return after a course, do not simply keep restarting indefinitely. A review can check whether the diagnosis is right, whether another medicine contributes, and whether testing for Helicobacter pylori or a specialist assessment is needed.

Do not miss the warning signs

Ask for urgent medical advice if food sticks or swallowing is painful, you vomit blood, pass black stools, have persistent vomiting, unexplained weight loss, anaemia or a new persistent symptom pattern. Call 999 for severe chest pain, especially with breathlessness, sweating or pain spreading to the arm, jaw or back.

Long-term PPI treatment can be appropriate for some conditions, but it should have a clear indication and periodic review. Always mention all prescribed and non-prescribed medicines during an assessment.

Sources

This guide is for general information. It cannot diagnose you or confirm that a medicine is safe for you. A clinician must assess your individual health and medicines. Call 999 in an emergency or contact NHS 111 for urgent advice.